Increasing recognition of the influence of norms supporting inequitable gender relations on HIV/STI risk and partner violence has led to the development of innovative programmes aimed at reducing this. This manual is adapted from once such programme, “Program H: Working with Young Men Series”, developed in Brazil by Instituto PROMUNDO. It is aimed at both government and non-government organizations (NGOs) aiming to promote gender equity and address masculinity as a strategy for the prevention of HIV infection. This manual promotes the positive aspects of masculinity, encouraging men’s participation in sexual and reproductive health, promotes respect for sexual diversity and improves the understanding of the body and sexuality. HIV prevention is addressed within the larger framework of gender roles and relationships.